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Proceedings Paper

Temperature dependent terahertz spectroscopy of azithromycin dihydrate
Author(s): Meijiao Huang; Jian Zuo; Cunlin Zhang
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Paper Abstract

Terahertz time-domain spectroscopy (THz-TDS) is a sensitive technique to characterize vibrational modes. It is widely used to monitor polymorphism of solids. This study investigated the terahertz (THz) absorption spectra of azithromycin dihydrate over a temperature range from 90 to 300 k to access more information about the structure and vibrational dynamics of hydrates. As the temperature was increased, the absorption peaks became wider and shifted towards lower frequencies. The temperature dependence of the absorption spectra was explained by the anharmonicity of the vibrational potentials. This method provides more information to characterize the temperature dependence of hydrate structures and contributes to the quality monitoring for the pharmaceutical industry.

Paper Details

Date Published: 12 March 2020
PDF: 6 pages
Proc. SPIE 11441, 2019 International Conference on Optical Instruments and Technology: IRMMW-THz Technologies and Applications, 1144108 (12 March 2020); doi: 10.1117/12.2542283
Show Author Affiliations
Meijiao Huang, Capital Normal Univ. (China)
Jian Zuo, Capital Normal Univ. (China)
Cunlin Zhang, Capital Normal Univ. (China)


Published in SPIE Proceedings Vol. 11441:
2019 International Conference on Optical Instruments and Technology: IRMMW-THz Technologies and Applications
Cunlin Zhang; Xi-Cheng Zhang; Zhiming Huang, Editor(s)

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