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Proceedings Paper

Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging
Author(s): Zhen Yuan; Duyang Gao
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Paper Abstract

Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, DTPA-Gd3+ is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the asobtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual -modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel asprepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new anenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

Paper Details

Date Published: 21 February 2020
PDF: 11 pages
Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540K (21 February 2020); doi: 10.1117/12.2542233
Show Author Affiliations
Zhen Yuan, Univ. of Macau (Macao, China)
Duyang Gao, Univ. of Macau (Macao, China)


Published in SPIE Proceedings Vol. 11254:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII
Dror Fixler; Ewa M. Goldys, Editor(s)

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