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Proceedings Paper

Multimodal imaging microscope for intraoperative detection of breast tumors positive margins (Conference Presentation)

Paper Abstract

Identification of positive margins during breast cancer conserving surgery is crucial for successful tumor resection. To address this clinical need, we developed a microscope that combines fluorescent microscopy, optical coherence tomography (OCT), and reflectance confocal microscopy (RCM) to identify the presence of positive tumor margins in surgical specimens. A cancer-targeting fluorescent agent is used to highlight potentially positive margins and guide combined RCM/OCT imaging. Combined RCM/OCT is used to accurately determine the extent of the positive margins, aided by custom image-processing techniques. This instrument has the potential to provide tumor margin guidance in the surgical suite, reducing reliance on lengthy histopathological inquiry and reducing the need for repeated surgery.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII, 112291B (9 March 2020); doi: 10.1117/12.2542059
Show Author Affiliations
Mark T. Scimone, Physical Sciences Inc. (United States)
Gopi N. Maguluri, Physical Sciences Inc. (United States)
Jesung Park, Physical Sciences Inc. (United States)
John Grimble, Physical Sciences Inc. (United States)
Savitri Krishnamurthy, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Nicusor V. Iftimia, Physical Sciences Inc. (United States)


Published in SPIE Proceedings Vol. 11229:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII
Anita Mahadevan-Jansen, Editor(s)

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