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Proceedings Paper

In vivo diagnosis of idiopathic pulmonary fibrosis (IPF) using endobronchial OCT (Conference Presentation)
Author(s): Sreyankar Nandy; Benjamin W. Roop; David C. Adams; Ashok Muniappan; Colleen M. Keyes; John C. Wain; Christopher R. Morse; Michael Lanuti; Thomas V. Colby; Angela Shih; Mari Mino-Kenudson; Eugene J. Mark; Richard L. Kradin; Amita Sharma; Lloyd Liang; Diane L. Davies; Margit V. Szabari; Andrew M. Tager; Melissa J. Suter; Lida P. Hariri

Paper Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of interstitial lung disease (ILD). High-resolution CT (HRCT) is currently used to identify macroscopic IPF features. However, for 50% of patients, ultimate diagnosis relies on microscopic features from invasive, high-risk surgical biopsies (SLBX). We conducted a pilot study to assess endobronchial OCT (EB-OCT) for in vivo diagnosis of IPF, enrolling ILD patients with nondiagnostic HRCT undergoing SLBX. EB-OCT visualized salient IPF features, including microscopic features not visible on HRCT, and accurately diagnosed IPF and non-IPF ILD as compared with SLBX. EB-OCT has the potential for in vivo microscopic diagnosis of IPF.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11214, Endoscopic Microscopy XV, 112140B (6 March 2020); doi: 10.1117/12.2541981
Show Author Affiliations
Sreyankar Nandy, Massachusetts General Hospital (United States)
Benjamin W. Roop, Massachusetts General Hospital (United States)
David C. Adams, Massachusetts General Hospital (United States)
Ashok Muniappan, Massachusetts General Hospital (United States)
Colleen M. Keyes, Massachusetts General Hospital (United States)
John C. Wain, Massachusetts General Hospital (United States)
Christopher R. Morse, Massachusetts General Hospital (United States)
Michael Lanuti, Massachusetts General Hospital (United States)
Thomas V. Colby, Mayo Clinic (United States)
Angela Shih, Massachusetts General Hospital (United States)
Mari Mino-Kenudson, Massachusetts General Hospital (United States)
Eugene J. Mark, Massachusetts General Hospital (United States)
Richard L. Kradin, Massachusetts General Hospital (United States)
Amita Sharma, Massachusetts General Hospital (United States)
Lloyd Liang, Massachusetts General Hospital (United States)
Diane L. Davies, Massachusetts General Hospital (United States)
Margit V. Szabari, Massachusetts General Hospital (United States)
Andrew M. Tager, Massachusetts General Hospital (United States)
Melissa J. Suter, Massachusetts General Hospital (United States)
Lida P. Hariri, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11214:
Endoscopic Microscopy XV
Guillermo J. Tearney M.D.; Thomas D. Wang; Melissa J. Suter, Editor(s)

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