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Proceedings Paper

Towards in vivo PA imaging of vulnerable plaques in carotid arteries (Conference Presentation)
Author(s): Min Wu; Elcke Vloedgraven; Roy van Hees; Jan-Willem Muller; Marc Van Sambeek; Frans van de Vosse; Richard Lopata; Hans-Martin Schwab

Paper Abstract

Rupture of carotid plaques triggers stroke. Current diagnosis of stroke is based on lumen stenosis, resulting in sever overtreatment. Photoacoustic (PA) imaging can provide comprehensive and patient-specific assessment of plaque vulnerability, and prevent overtreatment. However, no in vivo PA imaging of carotid plaque is available due to low SNR. Here, we present a fast PA/US imaging system and motion corrected averaging algorithm to increase PA SNR. The imaging system and algorithm are verified ex vivo, and in vivo on patients during carotid endarterectomy (intra-operatively). The results may accelerate the clinical translation of PA imaging of carotid plaques.

Paper Details

Date Published: 20 April 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124005 (20 April 2020); doi: 10.1117/12.2541946
Show Author Affiliations
Min Wu, Technische Univ. Eindhoven (Netherlands)
Elcke Vloedgraven, Technische Univ. Eindhoven (Netherlands)
Roy van Hees, Technische Univ. Eindhoven (Netherlands)
Jan-Willem Muller, Technische Univ. Eindhoven (Netherlands)
Marc Van Sambeek, Catharina Hospital (Netherlands)
Technische Univ. Eindhoven (Netherlands)
Frans van de Vosse, Technische Univ. Eindhoven (Netherlands)
Richard Lopata, Technische Univ. Eindhoven (Netherlands)
Hans-Martin Schwab, Technische Univ. Eindhoven (Netherlands)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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