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Quantitative biosensing by surface-enhanced Raman scattering
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Paper Abstract

Since its discovery in the 1970s, surface-enhanced Raman scattering (SERS) has attracted interest as a sensitive technique for detecting a wide range of analytes. However, SERS is a complex physicochemical phenomenon and tends to suffer from poor levels of reproducibility, which has hindered its translation into practical applications. Here we confirm that the low wavenumber pseudoband arising from the interaction between the edge filter and the elastically scattered light from the laser excitation can be used to perform "hotspot" normalisation of SERS spectra. Together with judicious use of resonant Raman scattering and/or careful control of the surface chemistry, this breakthrough in spectral data processing can address many of the challenges encountered when developing a quantitative SERS-based assay.

Paper Details

Date Published: 30 December 2019
PDF: 2 pages
Proc. SPIE 11202, Biophotonics Australasia 2019, 112020W (30 December 2019); doi: 10.1117/12.2541321
Show Author Affiliations
Md Abdullah Al Mamun, Swinburne Univ. of Technology (Australia)
Nerida A. Cole, Swinburne Univ. of Technology (Australia)
Saulius Juodkazis, Swinburne Univ. of Technology (Australia)
Paul R. Stoddart, Swinburne Univ. of Technology (Australia)


Published in SPIE Proceedings Vol. 11202:
Biophotonics Australasia 2019
Ewa M. Goldys; Brant C. Gibson, Editor(s)

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