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Proceedings Paper

Optical access to the brain through a transparent cranial implant
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Paper Abstract

Laser-based diagnostics and therapeutics show promise for many neurological disorders. However, the poor transparency of the cranial bone limits the spatial resolution and interaction depth that can be achieved with these technologies. We have recently demonstrated a new method to address this challenge in biomedical research through the use of a novel transparent cranial implant made from nanocrystalline yttria-stabilized zirconia (ncYSZ). In addition, we have also explored the use of optical clearing agents (OCAs) to achieve a local, reversible and temporal reduction of the scalp scattering prior light irradiation. Our results show that the transparent nc-YSZ implants coupled with the OCAs perform well in providing enhanced optical access to the brain tissue, without need for recurrent craniotomies or scalp removal.

Paper Details

Date Published: 21 February 2020
PDF: 8 pages
Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341A (21 February 2020); doi: 10.1117/12.2541042
Show Author Affiliations
Mildred S. Cano-Velázquez, Univ. Nacional Autónoma de México (Mexico)
Nami Davoodzadeh, Univ. of California, Riverside (United States)
David Halaney, Univ. of California, Riverside (United States)
Carrie R. Jonak, Univ. of California, Riverside (United States)
Devin K. Binder, Univ. of California, Riverside (United States)
Juan Hernández-Cordero, Univ. Nacional Autónoma de México (Mexico)
Guillermo Aguilar, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 11234:
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Robert R. Alfano; Stavros G. Demos; Angela B. Seddon, Editor(s)

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