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Lab-on-fiber SERS substrates for biomolecular recognition
Author(s): G. Quero; G. Zito; S. Managò; F. Galeotti; M. Pisco; Anna C. De Luca; A. Cusano
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Paper Abstract

We report on our activities related to the development of surface enhanced Raman scattering (SERS) probes realized onto the optical fiber tip (OFT) through nanosphere lithography. In the first stage of our research, we adapted the nanosphere lithography to operate on the optical fiber tip, by assessing the process and demonstrating either the potentiality or the repeatability of the proposed nanopatterning approach. Successively, we investigated the ability of the manufactured structures on the fiber tip to act as SERS probes by measuring the SERS spectra in presence of a Biphenyl Thiol (BPT) monolayer. Firstly, we focused the attention on the samples shaped as closed packed array of nanospheres covered by gold. The analysis allowed us to identify the most promising SERS platform, exhibiting an Enhancement Factor (EF) of 4×105 and a SERS measurements variability lower than 10%. We addressed also the limitations related to the use of the same optical fiber for both illumination and light collection by selecting a commercial optical fiber exhibiting a suitable trade-off in terms of high excitation/collection efficiency and low silica background. Current activities are devoted to the investigation of other nanopatterns on the optical fiber tip (namely, Sparse Array of metallodielectric spheres) and the analysis of the probes response against different molecules.

Paper Details

Date Published: 28 August 2019
PDF: 4 pages
Proc. SPIE 11199, Seventh European Workshop on Optical Fibre Sensors, 111991C (28 August 2019); doi: 10.1117/12.2540651
Show Author Affiliations
G. Quero, Univ. degli Studi del Sannio (Italy)
G. Zito, Institute of Protein Biochemistry, National Research Council (Italy)
S. Managò, Institute of Protein Biochemistry, National Research Council (Italy)
F. Galeotti, Institute for Macromolecular Studies, CNR (Italy)
M. Pisco, Univ. degli Studi del Sannio (Italy)
Anna C. De Luca, Institute of Protein Biochemistry, National Research Council (Italy)
A. Cusano, Univ. degli Studi del Sannio (Italy)


Published in SPIE Proceedings Vol. 11199:
Seventh European Workshop on Optical Fibre Sensors
Kyriacos Kalli; Sinead O. O'Keeffe; Gilberto Brambilla, Editor(s)

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