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Proceedings Paper

Optically measuring nerve activity based on an electro-optical detection system
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Paper Abstract

Nerve conduction and activity is a marker of disease and wellness and provides insight into the complex way the nervous system encodes information. We propose an electro-optical detection system and show the recordings from an electrically stimulated in-vitro nerve preparation. The system converts the action potential at the probing position to light intensity before any amplification and detection. Thence the light signal is detected by a photodetector. The new detection system has the ability of isolating the probing point and the amplification circuits, which reduces the electrical interference from the circuit. Moreover, the sampled signal transmitted via optical fibres rather than cables or wires makes it more robust to environmental noise. From the experiment, we demonstrated that the electro-optical detection system is able to detect and amplify the nerve response. By analysing the data, we can distinguish the response from the stimulus artifact and calculate CAP (compound action potential) propagation speed.

Paper Details

Date Published: 30 December 2019
PDF: 2 pages
Proc. SPIE 11202, Biophotonics Australasia 2019, 112021K (30 December 2019); doi: 10.1117/12.2540053
Show Author Affiliations
Yuan Wei, The Univ. of New South Wales (Australia)
Amr Al Abed, The Univ. of New South Wales (Australia)
Nathalie Gouailhardou, The Univ. of New South Wales (Australia)
Han Wang, The Univ. of New South Wales (Australia)
Xinyue Lei, The Univ. of New South Wales (Australia)
François Ladouceur, The Univ. of New South Wales (Australia)
Torsten Lehmann, The Univ. of New South Wales (Australia)
Nigel H. Lovell, The Univ. of New South Wales (Australia)
Leonardo Silvestri, The Univ. of New South Wales (Australia)

Published in SPIE Proceedings Vol. 11202:
Biophotonics Australasia 2019
Ewa M. Goldys; Brant C. Gibson, Editor(s)

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