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Optical fiber based in-vivo oxidative stress biosensor
Author(s): Roman Kostecki; Bin Zhang; Abdeljalil El Habti; Azim Arman; Mark R. Hutchinson; Penny J. Tricker; Delphine Fleury; Roger J. Narayan; Heike Ebendorff-Heidepriem
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Paper Abstract

Oxygen metabolism is a necessary process that takes place in animals and plants. Our cells and plant cells produce free radicals known as reactive oxygen species (ROS) continuously as a byproduct of oxygen metabolism and reaction to various environmental stresses, which must be normalized to avoid oxidative stress. Oxidative stress is intimately linked to cellular energy balance and occurs when there’s an imbalance between production and accumulation of ROS in cells and tissues and the ability of a biological system to keep in a redox steady state. We show preliminary results of an optical fiber based reversible in-vivo biosensor for understanding redox balance within living systems. The biosensor measured protein carbonyls (a marker of oxygen metabolism and oxidative stress) in pig-skin, live mouse, and wheat plant.

Paper Details

Date Published: 30 December 2019
PDF: 2 pages
Proc. SPIE 11202, Biophotonics Australasia 2019, 112020R (30 December 2019); doi: 10.1117/12.2539920
Show Author Affiliations
Roman Kostecki, The Univ. of Adelaide (Australia)
Bin Zhang, The Univ. of North Carolina (United States)
North Carolina State Univ. (United States)
Abdeljalil El Habti, The Univ. of Adelaide (Australia)
Azim Arman, The Univ. of Adelaide (Australia)
Mark R. Hutchinson, The Univ. of Adelaide (Australia)
Penny J. Tricker, The Univ. of Adelaide (Australia)
Delphine Fleury, The Univ. of Adelaide (Australia)
Roger J. Narayan, The Univ. of North Carolina (United States)
North Carolina State Univ. (United States)
Heike Ebendorff-Heidepriem, The Univ. of Adelaide (Australia)


Published in SPIE Proceedings Vol. 11202:
Biophotonics Australasia 2019
Ewa M. Goldys; Brant C. Gibson, Editor(s)

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