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Proceedings Paper

UV-LED device effectively increases serum levels of 25(OH)D3 in osteoporosis rats
Author(s): Yunqi Li; Haixia Qiu; Hongyou Zhao; Biao Chang; Tengda Ji M.D.; Yidi Liu; Ying Gu
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Paper Abstract

Osteoporosis is a bone disease associated with aging. As the population ages, osteoporosis has become a significant public health problem that threaten life quality of most countries in the world. Adequate vitamin D is able to improve intestinal calcium absorption, promote bone mineralization, maintain muscle strength, enhance balancing ability, and reduce fall risks, whichplays a vital role in bone metabolism. Moreover, vitamin D is mainly produced by ultraviolet (UV) light. The serum levels of 25(OH)D3 is the tools for estimating of the osteoporosis.It is known that vitamin D deficiency is ubiquitous in the elderly population, hence, we adopted UV light-emitting diode (UV-LED) instruments to generate narrow-range wavelengths of UV and determined its capability for producing vitamin D. The osteoporosis SD rats are our research subjects. The study was to investigate the effects of UV-LEDs of different power densities on vitamin D production. There are 4 groups:0.1, 0.2, 0.4, 0.8mW/cm2 and the rats (n = 6 per group) were irradiated with different power densities twice a week for a total of 8 weeks. The results showed that serum 25(OH)D3 levels rapidly increased in all irradiated groups compared with those in the control group (P < 0.001 in all groups), and 25(OH)D3 level of the rats in groups of both 0.4 and 0.8 m W/cm2 were able to return to the initial level at the fourth week after irradiation, besides, the group of 0.4 mW/ W/cm2 can achieve and maintain the highest25(OH)D3 level and so as the group of 0.8 m W/cm2 as the continuing irradiation. We demonstrate that the proper irradiation density of UV-LED irradiation can increase the production of vitamin D in rats and does not adversely affect the skin of rats.

Paper Details

Date Published: 20 November 2019
PDF: 10 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111903A (20 November 2019); doi: 10.1117/12.2537833
Show Author Affiliations
Yunqi Li, Chinese PLA General Hospital (China)
Haixia Qiu, Chinese PLA General Hospital (China)
Hongyou Zhao, Chinese PLA General Hospital (China)
Biao Chang, Chinese PLA General Hospital (China)
Tengda Ji M.D., Chinese PLA General Hospital (China)
Yidi Liu, Chinese PLA General Hospital (China)
Ying Gu, Chinese PLA General Hospital (China)


Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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