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Finite element modeling of mechanical properties of cancer cells
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Paper Abstract

Cellular mechanical properties are an important indicator for assessing and analyzing the functions of cells. However, the structure and compositions of the cell are complex. In order to analyze the effects of different components on the mechanical properties of cells, a multi-structured 3D model of cancer cells considering the cytoskeleton, cytoplasm, nucleus and cell membrane was established by finite element method. And the tensegrity structure-finding algorithm was used to analyze the cytoskeletal distribution and the pre-stress of each component. First, the model was verified by comparing numerical results with force-indentation curve obtained by atomic force microscopy in Ho-8910 cells. Then, the elasticity modulus of cell were obtained via applying a load to the established model.Computational simulation showed that cytoskeleton are the major component targeted in resisting compression.In addition, this model can provide useful guidance for the measurement and analysis of single cell through atomic force microscopy.

Paper Details

Date Published: 20 November 2019
PDF: 7 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 1119038 (20 November 2019); doi: 10.1117/12.2537819
Show Author Affiliations
Jiangbing Mao, Fujian Normal Univ. (China)
Weiwei Ruan, Fujian Normal Univ. (China)
Mengdan Chen, Fujian Normal Univ. (China)
Yuhua Wang, Fujian Normal Univ. (China)
Hongqin Yang, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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