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Proceedings Paper

Preliminary study of sonodynamic effects of a novel water soluble chlorin
Author(s): Jiang Jie; Jian Zou; Rui Ding; Zhen Han; Weijun Li; Zheng Huang
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Paper Abstract

Early studies suggest that some PDT photosensitizers can be used as sonosensitizer for sonodynamic therapy (SDT). In this study, sonodynamic effects of a novel water soluble chlorin YLG-1 were evaluated. SDT of YLG-1 solution was carried out using an ultrasound transducer of 450 KHz at 2.0 W/cm2 for 0 – 600 s. Comparison of spectroscopic profiles of YLG-1 before and after SDT demonstrated that sonification could cause the reduction of YLG-1 absorbance and fluorescence emission but did not cause obvious change of the Raman spectrum. No significant by-products were identified from spectroscopic study. Nevertheless, this study demonstrated that the sonification mediated sensitizer fluorescence bleaching effect could be partially blocked by the addition of NaN3, which suggests a possible involvement of singlet oxygen in the process of sonification of YLG-1 compound.

Paper Details

Date Published: 20 November 2019
PDF: 7 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 1119016 (20 November 2019); doi: 10.1117/12.2537785
Show Author Affiliations
Jiang Jie, Fujian Normal Univ. (China)
Jian Zou, Fujian Normal Univ. (China)
Rui Ding, Guilin Hui-ang Biopharmoceutic Co., Ltd. (China)
Zhen Han, Guilin Hui-ang Biopharmoceutic Co., Ltd. (China)
Weijun Li, Fujian Normal Univ. (China)
Zheng Huang, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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