Share Email Print

Proceedings Paper

Identifying pulmonary Cryptococcus neoformans infection by serum surface-enhanced Raman spectroscopy
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Cryptococcus neoformans is an encapsulated fungus that widely exists in the environment through the world. It can enter the human body through the respiratory tract, causing inflammation of the lungs and even causing serious infectious diseases in patients with impaired immune function. Those serious infectious diseases can be avoided if the cryptococcal pneumonia can be early detected and accurately assessed. However, due to less clinical symptoms, cryptococcal pneumonia is easily misdiagnosed as lung cancer, tuberculosis, etc., and the rate of misdiagnosis is high. Therefore, a rapid, accurate and non-invasive method is urgently needed to make early diagnosis and precise assessment of cryptococcal pneumonia, in which timely and appropriate treatment can be implemented and the cure rate is expected to be significantly improved. In this study, surface enhanced Raman spectroscopy (SERS) was served as the diagnostic tool to identify cryptococcal pneumonia, in which the blood serum SERS spectra are collected from cryptococcal pneumonia mice and uninfected mice. The multivariate curve resolution alternating least squares (MCR-ALS) and support vector machine (SVM) are employed to quantify the biochemical composition changes in serum microenvironments. The excellent results have demonstrated that the serum SERS has significant potential in early diagnosis and accurate assessment of cryptococcal pneumonia.

Paper Details

Date Published: 20 November 2019
PDF: 5 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111902U (20 November 2019); doi: 10.1117/12.2537660
Show Author Affiliations
Hao Lin, Northeastern Univ. (China)
He Zhang, Northeastern Univ. (China)
Jiaming Chen, Northeastern Univ. (China)
Qinke Zhang, Northeastern Univ. (China)
Zihui Fan, Northeastern Univ. (China)
Shuo Chen, Northeastern Univ. (China)

Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?