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Proceedings Paper

Imaging depth extension of optical coherence tomography by optical clearing method in vitro rabbit eye
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Paper Abstract

Optical coherence tomography (OCT) is a noninvasive, non-contact imaging technique, which is an indispensable diagnostic tool in ophthalmology. However, light attenuation in opaque tissues of the eye limits the imaging depth of OCT. In this study, the imaging depth of rabbit eye in vitro was extended by reduction of multiple scattering by using tissue optical clearing (TOC) agents. Results showed that with the application of glycerol in anterior segment, boundaries of ciliary muscle could be obviously differentiated. For posterior segment, the retina, the choroid, the sclera and even the eye container were also clearly imaged. All the physiology change by glycerol was recovered by a direct wash of saline in a short time.

Paper Details

Date Published: 20 November 2019
PDF: 7 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111900R (20 November 2019); doi: 10.1117/12.2537551
Show Author Affiliations
Ruiming Kong, Shanghai Institute of Technology (China)
Wenjuan Wu, Shanghai Institute of Technology (China)
Hongwei Zhao, Shanghai Institute of Technology (China)
Rui Qiu, Shanghai Institute of Technology (China)
Guoqiang Li, The Ohio State Univ. (United States)
Ailin Liu, Fudan Univ. (China)
Xinmin Lu, Shanghai Sixth People's Hospital (China)
Cuixia Dai, Shanghai Institute of Technology (China)


Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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