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Proceedings Paper

Simulation of spatial and temporal distribution of singlet oxygen in port wine stain during vascular targeted photodynamic therapy
Author(s): Linxin Li; Lina Liu; Ying Wang; Ying Gu; Buhong Li
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Paper Abstract

Vascular-targeted photodynamic therapy (V-PDT) has been demonstrated to be an effective treatment modality for nonmalignant diseases such as capillary malformations port wine stains (PWS). V-PDT treatment of PWS involves a complex interaction of light, photosensitizer (PS), oxygen and biological tissue. A three-dimensional (3D) model of PWS with a Y-bifurcation blood vessels was proposed for mathematical simulation of the spatial and temporal distribution of singlet oxygen (1O2), which related to the distribution of light, PS and oxygen. A graphics processing units (GPU)-based method, Monte Carlo eXtreme (MCX), was applied to calculate the light deposition in the PWS, and a set of differential equations were utilized to describe the photochemical reactions involved in V-PDT. Using the obtained light energy deposition and the distributions of the PS and oxygen, a dynamic change model of the cumulative concentration of 1O2 ([1O2]) was estimated. The data show that the smaller vessels are more likely to acquire more [1O2].

Paper Details

Date Published: 20 November 2019
PDF: 6 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111902D (20 November 2019); doi: 10.1117/12.2537441
Show Author Affiliations
Linxin Li, Fujian Normal Univ. (China)
Lina Liu, Fujian Normal Univ. (China)
Ying Wang, Chinese PLA General Hospital (China)
Ying Gu, Chinese PLA General Hospital (China)
Buhong Li, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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