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Proceedings Paper

High-speed intravascular photoacoustic imaging with blood flushing
Author(s): Chengyou Shu; Zhihua Xie; Daya Yang; Zhiyi Chen; Liang Song; Xiaojing Gong
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Paper Abstract

Intravascular photoacoustic imaging (IVPA) can obtain specific inflammation information and lipid composition in vivo, which is a new method for the diagnosis of atherosclerotic plaques. Numerous IVPA systems have been proposed and pushed towards clinical application. But imaging speed hinders their final clinical translation, considering necessary blood flush or balloon blood blockage operations during the intravascular intervention. In this study, we developed a high-speed IVPA system based on a 1064 nm pulsed laser, with the imaging speed of 60 round/second, about twice speed of the fastest IVPA system. In this system, a 0.9 mm outer diameter catheter was used for simultaneous IVPA and IVUS imaging. A plastic tube with an outer diameter of 1.3 mm was wrapped on the outside of the imaging catheter for protection and blood flushing channels. Firstly, the capability of high-speed imaging was verified by the imaging of a manually moving metal needle. Photoacoustic and ultrasonic images of the needle were obtained. No artifacts were found during the real-time imaging of the needle, which was unavoidable in the low-speed imaging system. Then, an artery excised from abdominal aorta of a New Zealand rabbit was sealed and a certain frequency of flowing water was injected from the one end to simulate the pulsation of blood vessels with a frequency of about 4.5 Hz, which was a typical heart rate of a rabbit. The high-speed IVPA-US imaging of pulsed blood vessels was successfully performed, which proved the feasibility of the system in vivo and even further clinical application.

Paper Details

Date Published: 20 November 2019
PDF: 6 pages
Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111901V (20 November 2019); doi: 10.1117/12.2537147
Show Author Affiliations
Chengyou Shu, Shenzhen Institutes of Advanced Technology (China)
Zhihua Xie, Shenzhen Institutes of Advanced Technology (China)
Daya Yang, Sun Yat-Sen Univ. (China)
Zhiyi Chen, Guangzhou Medical Univ. (China)
Liang Song, Shenzhen Institutes of Advanced Technology (China)
Xiaojing Gong, Shenzhen Institutes of Advanced Technology (China)

Published in SPIE Proceedings Vol. 11190:
Optics in Health Care and Biomedical Optics IX
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang; Dan Zhu, Editor(s)

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