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The biosensing of liver cancer cells based on the terahertz plasmonic metamaterials
Author(s): Maosheng Yang; Zhang Zhang; Lanju Liang; Xin Yan; Jianquan Yao; Dequan Wei; Longhai Liu; Yunxia Ye; Yunpeng Ren; Xundong Ren
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Paper Abstract

Real-time detection for living cells in vitro is essential for cell physiology, leading to a strong requirement of low cost and label free biosensors. At present, the terahertz plasmonic metamaterials (TPMMs) are an especially attractive application for biosensing owing to their sharp resonances respond. Compared with traditional biosensors, such as flow cytomertry, the TPMMs biosensors have many unique advantages, containing real-time monitoring, free label and high sensitivity. In this paper, we proposed a TPMMs which is designed by digging out periodically arranged regular hexagonal holes on the metal plate with the thickness of 200 nm. The samples of the TPMMs is used as a platform for detecting liver cancer cell GEP2 concentration at five levels (1 × 104, 5 × 104, 1 × 105, 3 × 105 and 5 × 105cells/ml). The results show that The THz PMMs biosensor cannot distinguish cell concentrations within the orders of magnitude between 1 × 104 and 5 × 104 cells/ml, however, it can distinguish cell concentrations within the orders of magnitude between 1 × 104 and 1 × 105 cells/ml based on the x-polarized reflection spectrum TPMMs biosensor. On the other hand, the transmission spectrum TPMMs biosensor has a significant detectability of the orders of magnitude cell concentration between 104 and 105 cells/ml. The proposed TPMMs biosensor paves a fascinating platform for have been widely applied for cell detection, biotechnology.

Paper Details

Date Published: 18 November 2019
PDF: 7 pages
Proc. SPIE 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI, 111960E (18 November 2019); doi: 10.1117/12.2536419
Show Author Affiliations
Maosheng Yang, Jiangsu Univ. (China)
Zhang Zhang, Tianjin Univ. (China)
Lanju Liang, Zaozhuang Univ. (China)
Xin Yan, Zaozhuang Univ. (China)
Jianquan Yao, Tianjin Univ. (China)
Dequan Wei, Zaozhuang Univ. (China)
Longhai Liu, Tianjin Univ. (China)
Yunxia Ye, Jiangsu Univ. (China)
Yunpeng Ren, Jiangsu Univ. (China)
Xundong Ren, Jiangsu Univ. (China)


Published in SPIE Proceedings Vol. 11196:
Infrared, Millimeter-Wave, and Terahertz Technologies VI
Cunlin Zhang; Xi-Cheng Zhang; Masahiko Tani, Editor(s)

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