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Proceedings Paper

Biosensor platforms of the polarization-dependent metamaterials for the detection of cancer-cell concentration
Author(s): Z. Zhang; M. Yang; Lan-Ju Liang; X. Yan; Y. Lu; D. Wei; J. Yao
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Paper Abstract

The rapid detection of cancer cells is crucial for clinical diagnosis in biomedical field. The traditional flow cytometry (FC) in visible band, a fluorescence-labelling detection, gives rise to the complicated sample preparation and the irrecoverable antibody consumption; it blocks the development toward a convenient detection platform with fast, inexpensive and non-labelling. Here, a specifically designed metamaterial based on split ring resonators (SRRs) is proposed. Such metamaterial operating in terahertz (THz) range exhibits polarization-dependent resonances, which are observed both in experiments and simulations. Additionally, the biosensing property of the metamaterial is investigated. On metamaterial surfaces, the lung cancer cells A549 are cultured. Under the irradiation of x-polarized THz waves, it is found that for the cell concentrations from 1×105 cells/ml to 5×105 cells/ml, the maximum frequency shift Δf (the frequency difference between measured sample and bare one) at 2.24 THz increases from 15 GHz to 137 GHz, respectively. Such results also imply that a larger cell concentration leads to a higher frequency shift. Subsequently, the samples are further measured at different polarization angles. The results show that for cell concentration of 5×105 cells/ml, the Δf exhibits the same value of 130 GHz when polarization angle equals 30° and 150°, and 15 GHz when polarization angle equals 60° and 120°. Our proposed metamaterial may supply a potential biosensing method for the detection of cancer cells, exhibiting a new insight toward the cancer cell biosensing with certain information of polarization response.

Paper Details

Date Published: 18 November 2019
PDF: 6 pages
Proc. SPIE 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI, 111960X (18 November 2019); doi: 10.1117/12.2534423
Show Author Affiliations
Z. Zhang, Tianjin Univ. (China)
M. Yang, Jiangsu Univ. (China)
Lan-Ju Liang, Zaozhuang Univ. (China)
X. Yan, Zaozhuang Univ. (China)
Y. Lu, Tianjin Univ. (China)
D. Wei, Zaozhuang Univ. (China)
J. Yao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 11196:
Infrared, Millimeter-Wave, and Terahertz Technologies VI
Cunlin Zhang; Xi-Cheng Zhang; Masahiko Tani, Editor(s)

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