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Proceedings Paper

Magnetic particle composites as a non-invasive high-resolution brain-machine interface (Conference Presentation)
Author(s): Irving N. Weinberg; Lamar O. Mair; Sahar Jafari; Chad Ropp; Olivia Hale; Anjana Hevaganinge; Rutuja Kulkarni; Fair Vassoler; Luz Martinez-Miranda

Paper Abstract

We are developing a voltage-sensitive magnetic resonance imaging (MRI) contrast agent capable of detecting neuronal activity deep within the brain, as well as sensing activation in the peripheral nervous system. The contrast agent will allow nervous system activity to be read out by an external device, with spatial resolution of 30 microns and temporal resolution of 10 milliseconds. The field sensitivity appears to be as low as 20 volts/meter, which is several orders of magnitude higher than the sensitivity of optical contrast agents. We have also validated that injection of a similar particle can be used to initiate behavioral changes in mice upon application of an external changing magnetic field. The external field is about 10 mT, which can be produced with a wearable device. We have also validated the ability to magnetically inject particles into the brain (in mice) intra-nasally, with efficiency that is several hundred times higher than non-magnetic inhalation. The combination of these two products will be useful as a neuroscience/neuroengineering imaging tool, a clinical diagnostic tool, and, in the future, as a robust brain-machine interface

Paper Details

Date Published: 9 September 2019
Proc. SPIE 11087, Biosensing and Nanomedicine XII, 1108708 (9 September 2019); doi: 10.1117/12.2532453
Show Author Affiliations
Irving N. Weinberg, Weinberg Medical Physics (United States)
Lamar O. Mair, Weinberg Medical Physics (United States)
Sahar Jafari, Weinberg Medical Physics (United States)
Chad Ropp, Weinberg Medical Physics (United States)
Olivia Hale, Weinberg Medical Physics (United States)
Anjana Hevaganinge, Weinberg Medical Physics (United States)
Rutuja Kulkarni, Weinberg Medical Physics (United States)
Fair Vassoler, Tufts College (United States)
Luz Martinez-Miranda, Univ. of Maryland, College Park (United States)

Published in SPIE Proceedings Vol. 11087:
Biosensing and Nanomedicine XII
Hooman Mohseni; Massoud H. Agahi, Editor(s)

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