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Proceedings Paper

MARS pre-clinical imaging: the benefits of small pixels and good energy data
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Paper Abstract

Images from MARS spectral CT scanners show that there is much diagnostic value from using small pixels and good energy data. MARS scanners use energy-resolving photon-counting CZT Medipix3RX detectors that measure the energy of photons on a five-point scale and with a spatial resolution of 110 microns. The energy information gives good material discrimination and quantification. The 3D reconstruction gives a voxel size of 70 microns. We present images of pre-clinical specimens, including excised atheroma, bone and joint samples, and nanoparticle contrast agents along with images from living humans. Images of excised human plaque tissue show the location and extent of lipid and calcium deposition within the artery wall. The presence of intraplaque haemorrhage, where the blood leaks into the artery wall following a rupture, has also been visualised through the detection of iron. Several clinically important bone and joint problems have been investigated including: site-specific bone mineral density, bone-metal interfaces (spectral CT reduces metal artefacts), cartilage health using ionic contrast media, gout and pseudogout crystals, and microfracture assessment using nanoparticles. Metallic nanoparticles have been investigated as a cellular marker visible in MARS images. Cell lines of different cancer types (Raji and SK-BR3) were incubated with monoclonal antibody-functionalised AuNPs (Herceptin and Rituximab). We identified and quantified the labelled AuNPs demonstrating that Herceptin-functionalised AuNPs bound to SK-BR3 breast cancer cells but not to the Raji lymphoma cells. In vivo human images show the bone microstructure. Fat, water, and calcium concentrations are quantifiable.

Paper Details

Date Published: 27 September 2019
PDF: 10 pages
Proc. SPIE 11113, Developments in X-Ray Tomography XII, 111130C (27 September 2019);
Show Author Affiliations
Philip H. Butler, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Univ. of Otago Christchurch (New Zealand)
Sikiru A. Adebileje, Univ. of Otago, Christchurch (New Zealand)
Univ. of Canterbury (New Zealand)
Steven D. Alexander, MARS Bioimaging Ltd. (New Zealand)
Maya R. Amma, Univ. of Otago, Christchurch (New Zealand)
Marzieh Amjomrouz, MARS Bioimaging Ltd. (New Zealand)
Fatemeh Asghariomabad, Univ. of Otago, Christchurch (New Zealand)
Ali Atharifard, MARS Bioimaging Ltd. (New Zealand)
James Atlas, Univ. of Canterbury (New Zealand)
Benjamin Bamford, Univ. of Otago, Christchurch (New Zealand)
Stephen T. Bell, MARS Bioimaging Ltd. (New Zealand)
Srinidhi Bheesette, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Anthony P. H. Butler, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Pierre Carbonez, Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Claire Chambers, Univ. of Canterbury (New Zealand)
Alexander I. Chernoglazov, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Jennifer A. Clark, Univ. of Otago, Christchurch (New Zealand)
Ara Institute of Canterbury (New Zealand)
Jonathan S. Crighton, Univ. of Otago, Christchurch (New Zealand)
Shishir Dahal, Univ. of Otago, Christchurch (New Zealand)
Ministry of Health (Nepal)
National Academy of Medical Sciences (Nepal)
Jérôme Damet, Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Lausanne Univ. Hospital (Switzerland)
Neils J. A. de Ruiter, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Robert M. N. Doesburg, MARS Bioimaging Ltd. (New Zealand)
Neryda Duncan, Univ. of Canterbury (New Zealand)
Nooshin Ghodsian, Univ. of Cantebury (New Zealand)
Steven P. Gieseg, Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Brian P. Goulter, MARS Bioimaging Ltd. (New Zealand)
Sam Gurney, Univ. of Otago, Christchurch (New Zealand)
Joseph L. Healy, MARS Bioimaging Ltd. (New Zealand)
Praveenkumar Kanithi, Univ. of Canterbury (New Zealand)
Tracy Kirkbride, Ara Institute of Canterbury (New Zealand)
Stuart P. Lansley, MARS Bioimaging Ltd. (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Chiara Lowe, Univ. of Otago, Christchurch (New Zealand)
V. B. H. Mandalika, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Emmanuel Marfo, Univ. of Otago, Christchurch (New Zealand)
Aysouda Matanaghi, Univ. of Otago, Christchurch (New Zealand)
Mahdieh Moghiseh, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
David Palmer, Lincoln Univ. (New Zealand)
Raj K. Panta, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (Switzerland)
Hannah M. Prebble, MARS Bioimaging Ltd. (New Zealand)
Aamir Y. Raja, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Yann Sayous, Univ. of Canterbury (New Zealand)
Peter Renaud, Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Nanette Schleich, Univ. of Otago, Wellington (New Zealand)
Emily Searle, Univ. of Canterbury (New Zealand)
Jereena S. Sheeja, Univ. of Otago, Christchurch (New Zealand)
Rayhan Uddin, Univ. of Canterbury (New Zealand)
Lieza Vanden Broeke, MARS Bioimaging Ltd. (New Zealand)
V. S. Vivek , MARS Bioimaging Ltd. (New Zealand)
E. Peter Walker, Univ. of Otago, Christchurch (New Zealand)
Michael F. Walsh, MARS Bioimaging Ltd. (New Zealand)
Manoj Wijesooriya, Univ. of Canterbury (New Zealand)
W. Ross Younger, MARS Bioimaging Ltd. (New Zealand)


Published in SPIE Proceedings Vol. 11113:
Developments in X-Ray Tomography XII
Bert Müller; Ge Wang, Editor(s)

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