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Proceedings Paper

Ex-vivo characterization of human healthy colon and colorectal cancer by multispectral Mueller polarimetric imaging and its polar decomposition
Author(s): Azael Mora-Núñez; Geminiano Martinez-Ponce; Guillermo García-Torales; Marija Strojnik; Beethoven Bravo-Medina; Luis Bernache-Santana
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Paper Abstract

Mueller matrix polarimetric imaging (MMPI) provides precise microstructural information of biological samples and has been applied to the detections of various abnormal tissues. Once the Mueller matrix is determined for a particular anisotropic material, polar decomposition is applied to determine the singular values of optical anisotropies, such as depolarization, diattenuation, retardance and optical rotation. In this work, ex-vivo cancerous and noncancerous tissues were imaged by the MMPI technique using 3 different radiation wavelengths (460, 532 and 633 nm). The samples under study were cancerous and noncancerous tissues from colon. The results show that the optical anisotropies from biological samples are different. As we know, cancer changes the structure and concentration of biomedical substances from healthy tissue. One of the structures that is affected by cancer is collagen. This structure contributes to the diatenuation and retardance values. Therefore the values of diatenuation and retardance are different from the malignant and healthy tissues. We demonstrate that MMPI and polar decomposition are useful tools to discriminate healthy tissue and cancerous tissue from different parts of the body.

Paper Details

Date Published: 9 September 2019
PDF: 8 pages
Proc. SPIE 11128, Infrared Remote Sensing and Instrumentation XXVII, 1112815 (9 September 2019); doi: 10.1117/12.2531113
Show Author Affiliations
Azael Mora-Núñez, Univ. de Guadalajara (Mexico)
Geminiano Martinez-Ponce, Centro de Investigaciones en Óptica, A.C. (Mexico)
Guillermo García-Torales, Univ. de Guadalajara (Mexico)
Marija Strojnik, Ctr. de Investigaciones en Óptica A.C. (Mexico)
Beethoven Bravo-Medina, Ctr. de Investigaciones en Óptica A.C. (Mexico)
Luis Bernache-Santana, Univ. de Guadalajara (Mexico)

Published in SPIE Proceedings Vol. 11128:
Infrared Remote Sensing and Instrumentation XXVII
Marija Strojnik; Gabriele E. Arnold, Editor(s)

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