Paper Abstract

The aim is to perform qualitative and quantitative assessment of metal induced artefacts of small titanium biomaterials using photon counting spectral CT. The energy binning feature of some photon counting detectors enables the measured spectrum to be segmented into low, mid and high energy bins in a single exposure. In this study, solid and porous titanium implants submerged in different concentrations of calcium solution were scanned using the small animal MARS photon counting spectral scanner equipped with a polyenergetic X-ray source operated at 118 kVp. Five narrow energy bins (7-45 keV, 45-55 keV, 55-65 keV, 65-75 keV and 75-118 keV) in charge summing mode were utilised. Images were evaluated in the energy domain (spectroscopic images) as well as material domain (material segmentation and quantification). Results show that calcium solution outside titanium implants can be accurately quantified. However, there was an overestimation of calcium within the pores of the scaffold. This information is critical as it can severely limit the assessment of bone ingrowth within metal structures. The energy binning feature of the spectral scanner was exploited and a correction factor, based on calcium concentrations adjacent to and within metal structures, was used to minimise the variation. Qualitative and quantitative evaluation of bone density and morphology with and without titanium screw shows that photon counting spectral CT can assess bone-metal interface with less pronounced artefacts. Quantification of bone growth in and around the implants would help in orthopaedic applications to determine the effectiveness of implant treatment and assessment of fracture healing.

Paper Details

Date Published: 10 September 2019
PDF: 8 pages
Proc. SPIE 11113, Developments in X-Ray Tomography XII, 111131D (10 September 2019); doi: 10.1117/12.2531003
Show Author Affiliations
Maya Rajeswari Amma, Univ. of Otago, Christchurch (New Zealand)
Anthony P. H. Butler, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Aamir Y. Raja, Univ. of Otago, Christchurch (New Zealand)
Benjamin Bamford, Univ. of Otago, Christchurch (New Zealand)
Philip Butler, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (CERN) (Switzerland)
E. Peter Walker, Univ. of Otago, Christchurch (New Zealand)
Aysouda Matanaghi, Univ. of Otago, Christchurch (New Zealand)
Sikiru A. Adebileje, Univ. of Otago, Christchurch (New Zealand)
Univ. of Canterbury (New Zealand)
Nigel Anderson, Univ. of Otago, Christchurch (New Zealand)
Marzieh Anjomrouz, MARS Bioimaging Ltd. (New Zealand)
Fatemeh Asghariomabad, Univ. of Otago, Christchurch (New Zealand)
Ali Atharifard, MARS Bioimaging Ltd. (New Zealand)
Stephen T. Bell, MARS Bioimaging Ltd. (New Zealand)
Srinidhi Bheesette, Univ. of Otago, Christchurch (New Zealand)
European Organisation for Nuclear Research (CERN) (Switzerland)
Alexander I. Chernoglazov, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Tara Dalefield, Univ. of Canterbury (New Zealand)
Neils J. A. de Ruiter, MARS Bioimaging Ltd. (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Univ. of Canterbury, Christchurch (New Zealand)
Neryda Duncan, Univ. of Canterbury (New Zealand)
Robert M. N. Doesburg, MARS Bioimaging Ltd. (New Zealand)
Steven Gieseg, Univ. of Otago, Christchurch (New Zealand)
Univ. of Canterbury, Christchurch (New Zealand)
Brian P. Goulter, MARS Bioimaging Ltd. (New Zealand)
Steven D. Alexander, Univ. of Canterbury (New Zealand)
Sam Gurney, Univ. of Otago, Christchurch (New Zealand)
Joseph L. Healy, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury (New Zealand)
Peter J. Hilton, Univ. of Canterbury (New Zealand)
Univ. of Otago, Christchurch (New Zealand)
Shishir Dahal, Univ. of Otago, Christchurch (New Zealand)
Ministry of Health and Population (Nepal)
National Academy of Medical Sciences (Nepal)
Pierre Carbonez, Univ. of Otago, Christchurch (New Zealand)
CERN (Switzerland)
Jerome Damet, Univ. of Otago, Christchurch (New Zealand)
CERN (Switzerland)
Institut de Radiophysique (Switzerland)
Claire Chambers, Univ. of Canterbury (New Zealand)
Praveenkumar Kanithi, Univ. of Canterbury (New Zealand)
Human Interface Technology Lab. New Zealand (New Zealand)
Tracy Kirkbride, Ara Institute of Canterbury (New Zealand)
Stuart P. Lansley, MARS Bioimaging Ltd. (New Zealand)
Chiara Lowe, Univ. of Otago, Christchurch (New Zealand)
V. B. H. Mandalika, MARS Bioimaging Ltd. (New Zealand)
Univ. of Canterbury, Christchurch (New Zealand)
Human Interface Technology Lab. New Zealand (New Zealand)
Emmanuel Marfo, Univ. of Otago, Christchurch (New Zealand)
Mahdieh Moghiseh, Univ. of Otago, Christchurch (New Zealand)
MARS Bioimaging Ltd. (New Zealand)
David Palmer, Lincoln Univ. (New Zealand)
Raj K. Panta, Univ. of Otago, Christchurch (New Zealand)
MARS Bioimaging Ltd. (New Zealand)
Hannah M. Prebble, MARS Bioimaging Ltd. (New Zealand)
Mohsen Ramyar, Univ. of Otago, Christchurch (New Zealand)
Peter Renaud, Univ. of Otago, Christchurch (New Zealand)
Univ. of Canterbury (New Zealand)
Nanette Schleich, Univ. of Otago, Christchurch (New Zealand)
Emily Searle, Univ. of Canterbury (New Zealand)
Muhammed Shamshad, MARS Bioimaging Ltd. (New Zealand)
Jereena S. Sheeja, Univ. of Otago, Christchurch (New Zealand)
Rayhan Uddin, Univ. of Canterbury (New Zealand)
Lieza Vanden Broeke, Univ. of Canterbury (New Zealand)
Vivek V. S., MARS Bioimaging Ltd. (New Zealand)
Manoj Wijesooriya, Univ. of Canterbury (New Zealand)
Michael F. Walsh, MARS Bioimaging Ltd. (New Zealand)
Kenzie Baer, Univ. of Otago, Christchurch (New Zealand)
Seamus Tredinnick, Univ. of Otago, Christchurch (New Zealand)
Tim Woodfield, Univ. of Otago, Christchurch (New Zealand)


Published in SPIE Proceedings Vol. 11113:
Developments in X-Ray Tomography XII
Bert Müller; Ge Wang, Editor(s)

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