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Engineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots
Author(s): Galina Nifontova; Maria Baryshnikova; Fernanda Ramos-Gomes; Frauke Alves; Igor Nabiev; Alyona Sukhanova
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Paper Abstract

Quantum dots (QDs) are fluorescent semiconductor nanocrystals with a high photostability, wide absorption spectra, and narrow, size-tunable emission spectra, which make them promising nanolabels to be encapsulated in microcarriers used as bioimaging and theranostic tools. Here, we describe an approach to the optical encoding of polyelectrolyte microcapsules with the prepared stable water-soluble QDs and key stages of surface functionalization of these microcapsules with cetuximab, humanised monoclonal anticancer antibody. Obtained conjugates demonstrate the specificity and efficiency of the engineered system as a cancer cell–targeted tracing tool that could be used for cancer diagnosis, treatment and monitoring of cancer therapy.

Paper Details

Date Published: 3 October 2019
PDF: 6 pages
Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112072D (3 October 2019); doi: 10.1117/12.2530281
Show Author Affiliations
Galina Nifontova, National Research Nuclear Univ. MEPhI (Russian Federation)
Maria Baryshnikova, National Research Nuclear Univ. MEPhI (Russian Federation)
N.N. Blokhin National Medical Research Ctr. of Oncology (Russian Federation)
Fernanda Ramos-Gomes, Max-Planck-Institute of Experimental Medicine (Germany)
Frauke Alves, Max-Planck-Institute of Experimental Medicine (Germany)
Univ. Medical Ctr. Göttingen (Germany)
Igor Nabiev, National Research Nuclear Univ. MEPhI (Russian Federation)
Lab. de Recherche en Nanosciences, CNRS, Univ. de Reims Champagne-Ardenne (France)
Alyona Sukhanova, Lab. de Recherche en Nanosciences, CNRS, Univ. de Reims Champagne-Ardenne (France)


Published in SPIE Proceedings Vol. 11207:
Fourth International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)

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