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Proceedings Paper

Photoluminescent silicon nanoparticles as a self-reporting nanomedicine (Conference Presentation)
Author(s): Yusung Jin; Goun Lee; Chan-Gi Pack; Jun Ki Kim; Jinmyoung Joo

Paper Abstract

Porous silicon nanoparticles (PSiNPs) have attracted increasing interest for imaging and treatment of diseases due to biocompatibility, large specific capacity for drug loading, non-toxic degradation products, and intrinsic photoluminescence (PL). In particular, the PL lifetime is typically on the order of microseconds, significantly longer than the nanosecond lifetimes exhibited by fluorescent molecules naturally presented in cells and tissues, thus allows discrimination of the silicon nanoparticle from the tissue autofluorescence. Herein, the long-lived PL is employed to monitor the status of drug payload elution, associated with biodegradation of the silicon nanocarriers, and demonstrated as a “self-reporting” system. Dissolution of the silicon matrix in physiological environment triggers drug release, along with decreasing intensity and blue shift of the PL spectra. Furthermore, by tracking the PL lifetime, the drug releasing status and the residual lifespan of the silicon nanocarriers are correspondingly acquired. The PL lifetime is a physically intensive property that can report only the inherent characteristics of the PSiNPs regardless of surrounding noise while the intensity-based reporting is substantially affected by many unwanted factors. We investigate a unique means to inform the lifespan of the PSiNPs as a biodegradable drug nanocarrier in vivo. This study presents a promising potential of the photoluminescent PSiNPs toward advanced drug delivery systems for translational medical platform including theranostics and visualized drug delivery tracking.

Paper Details

Date Published: 9 September 2019
Proc. SPIE 11087, Biosensing and Nanomedicine XII, 1108703 (9 September 2019); doi: 10.1117/12.2530145
Show Author Affiliations
Yusung Jin, Asan Medical Ctr. (Korea, Republic of)
Goun Lee, Asan Medical Ctr. (Korea, Republic of)
Chan-Gi Pack, Asan Medical Ctr. (Korea, Republic of)
Jun Ki Kim, Asan Medical Ctr. (Korea, Republic of)
Jinmyoung Joo, Ulsan National Institute of Science and Technology (Korea, Republic of)

Published in SPIE Proceedings Vol. 11087:
Biosensing and Nanomedicine XII
Hooman Mohseni; Massoud H. Agahi, Editor(s)

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