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Proceedings Paper

Research and development of effective optical technologies for diagnostics in dermatology
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Paper Abstract

Optical clearing of the human skin under the action of hyaluronic acid (HA) as an enhancer for optical clearing by polyethylene glycol (PEG-300) was studied in vivo by optical coherent tomography (OCT) method on the wavelength 930±5 nm. The results have showed an increase in the transparency of the epidermis at the optical depth of 50±5 μm by 44±9% within 15 min with the use of a solution of HA in combination with sonophoresis before application of PEG-300 to the skin surface. At the same time, when using PEG-300 without preliminary treatment of the skin with the HA, an increase in the transparency of the epidermis at the same depth was 21±8% within 25 min. In dermis at the depth of 500 μm the OCT signal in the experimental group increased more than 1.6 fold what indicates an increasing of optical probing depth.

Paper Details

Date Published: 3 June 2019
PDF: 8 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106505 (3 June 2019);
Show Author Affiliations
Vadim D. Genin, Saratov State Univ. (Russian Federation)
Prisca Rakotomanga, Univ. of Lorraine, CNRS, CRAN (France)
Sergey M. Zaytsev, Saratov State Univ. (Russian Federation)
Univ. of Lorraine, CNRS, CRAN (France)
Elina A. Genina, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Ekaterina N. Lazareva, Saratov State Univ. (Russian Federation)
Grégoire Khairallah, Univ. of Lorraine, CNRS, CRAN (France)
Marine Amouroux, Univ. of Lorraine, CNRS, CRAN (France)
Charles Soussen, Univ. of Lorraine, CNRS, CRAN (France)
Hang Chen, Univ. of Lorraine, CNRS, CRAN (France)
Wei Feng, Huazhong Univ. of Science and Technology (China)
Dan Zhu, Huazhong Univ. of Science and Technology (China)
Alexey N. Bashkatov, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Walter Blondel, Univ. of Lorraine, CNRS, CRAN (France)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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