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Proceedings Paper

Photoactivated chemotherapy in hypoxic cancer cells (Conference Presentation)
Author(s): Sylvestre Bonnet

Paper Abstract

Hypothesis: ruthenium-based photo activated chemotherapy compounds are activated by photo substitution, which is independent from the presence of dioxygen. Hence phytotoxicity is kept in hypoxic cancer cells. Method: we have developed a setup to shine light on living cancer cells in a controlled atmosphere, with the O2 concentration comprised between 1 and 21%. We use this setup to study the influence of hypoxia on the dose-response curve of a series of ruthenium-based photo activated compounds. Results: with different ruthenium compounds the photo index remains indeed independent on the concentration of O2. However, the IC50 in the dark and after light irradiation are often higher under hypoxia, compared to normoxia. Conclusion: photo activated chemotherapy compounds are indeed promising for killing hypoxic cancer cells, but synergistic effects may be needed to obtain high photo indexes under hypoxia.

Paper Details

Date Published: 14 August 2019
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110703I (14 August 2019); doi: 10.1117/12.2528324
Show Author Affiliations
Sylvestre Bonnet, Leiden Univ. (Netherlands)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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