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Proceedings Paper

The role of proteoglycan genes in PDT-resistant HEp-2 cells
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Paper Abstract

Optimizing the parameters of PDT for specific cancer cells by identifying the mechanisms involved in the process represents a considerable tool for the development of photosensitizer delivery systems and the improvement of PDT targets for cancer. Proteoglycans, important constituents of extracellular matrix (ECM) play an important role in both progression and inhibition of tumor development. This study determines by gene expression whether proteoglycan are associated with PDT resistance observed in human epidermoid larynx carcinoma cells (HEp-2). We conclude that PDT increases the expression of DECORIN and BIGLYCAN genes, involved in metastatic dissemination, leading to inhibitory effect growth in Hep-2 cells

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070AF (7 August 2019);
Show Author Affiliations
Cristina Pacheco-Soares, Univ. of Vale do Paraiba (Brazil)
Roberta Kelly de Faria Souza, Univ. of Vale do Paraiba (Brazil)
Isabel Chaves Silva Carvalho, Univ. of Vale do Paraiba (Brazil)
Renata A. Canevari, Univ. 13 of Vale do Paraiba (Brazil)
Bruno Henrique Godoi, Univ. of Vale do Paraiba (Brazil)
Carlos Dailton G. O. Moraes, Univ. of Vale do Paraiba (Brazil)
Ritchelli Ricci, Univ. of Vale do Paraiba (Brazil)
Juliana Ferreira Strixino, Univ. 13 of Vale do Paraiba (Brazil)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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