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Proceedings Paper

Light distribution monitoring using an IR navigation system for pleural PDT (Conference Presentation)
Author(s): Timothy C. Zhu; Michele M. Kim; Yihong Ong; Andreea Dimofte; Sunil Singhal; Keith A. Cengel

Paper Abstract

Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. We have developed an improved model for direct light calculation that accounts for the anisotropy of the light from the light sources. A comprehensive analysis of the distribution of light fluence during HPPH and Photofrin PDT is presented in clinical cases and the improvements between the two protocol are discussed.

Paper Details

Date Published: 20 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110705N (20 August 2019);
Show Author Affiliations
Timothy C. Zhu, Perelman Ctr. for Advanced Medicine (United States)
Michele M. Kim, Perelman Ctr. for Advanced Medicine, Univ. of Pennsylvania (United States)
Yihong Ong, Perelman Ctr. for Advanced Medicine, Univ. of Pennsylvania (United States)
Andreea Dimofte, Perelman Ctr. for Advanced Medicine, Univ. of Pennsylvania (United States)
Sunil Singhal, Univ. of Pennsylvania (United States)
Keith A. Cengel, Perelman Ctr. for Advanced Medicine, Univ. of Philadelphia (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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