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Meibomian gland loss area and its relationship with age and ocular surface disease index
Author(s): Jacobo Garcia-Queiruga; Hugo Pena-Verdeal; Dolores Ferreiro; Carlos García-Resua; Eva Yebra-Pimentel
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Paper Abstract

Purpose: Meibography images bring information about the status and integrity of the meibomian glands (MG). The aim of this study was to correlate the meibomian gland loss area (MGLA) with age and dry eye symptomatology. Material and methods: A total of 110 subjects were recruited for the study. From the Meibography images obtained with the Topcon® CA-800 topographer, MGLA was calculated as the difference between the total area of the tarsus and the MG presence area measured by using the ImageJ software. Before examination, all subjects completed an OSDI questionnaire. OSDI scores were grouped in 4 severity categories: normal (score ≤12), mild (score 12–22), moderate (score 22–32) and severe (score ≥32). Age were categorised in 3 subgroups: ≤25 years, from 25 to 45 years and ≥45 years. MGLA was also grouped in 4 categories of loss: ≤25 %, from 25 to 50%, from 50 to 75% and ≥75%. Results: Analysis was performed by dividing the sample in the 4 MGLA subgroups; these subgroups showed differences in age (p=0.029; Kruskal-Wallis test) and differences in OSDI scores (p=0.001; Kruskal-Wallis test). Sample was divided in 3 age subgroups and differences were obtained in MGLA values among subgroups (p<0.001; Kruskal-Wallis test). Samples was divided in 4 OSDI subgroups and differences were obtained in MGLA values among subgroups (p=0.003; Kruskal-Wallis test). Positive correlation (Spearman Correlation) were obtained for both, MGLA vs. age (r=0.329, p<0.001) and MGLA vs. OSDI (r=0.380, p<0.001). Conclusion: In the present study MGLA showed a relationship with age and OSDI.

Paper Details

Date Published: 3 October 2019
PDF: 5 pages
Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112071B (3 October 2019); doi: 10.1117/12.2527349
Show Author Affiliations
Jacobo Garcia-Queiruga, Univ. de Santiago de Compostela (Spain)
Hugo Pena-Verdeal, Univ. de Santiago de Compostela (Spain)
Dolores Ferreiro, Univ. de Santiago de Compostela (Spain)
Carlos García-Resua, Univ. de Santiago de Compostela (Spain)
Eva Yebra-Pimentel, Univ. de Santiago de Compostela (Spain)


Published in SPIE Proceedings Vol. 11207:
Fourth International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)

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