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Non-invasive optical assessment of intracranial pressure: pilot results in human patients
Author(s): Wesley B. Baker; Tracy M. Flanders; Ramani Balu; Lian He; Kristina Heye; Elizabeth Mahanna Gabrielli; John J. Flibotte; Daniel J. Licht; Gregory G. Heuer; Arjun G. Yodh; W. Andrew Kofke
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Paper Abstract

We present pilot results on the validation of non-invasive assessment of elevated intracranial pressure with optical measurement of critical closing pressure. A strong correlation (r=0.85) between optical measurements of critical closing pressure and invasive measurements of intracranial pressure was observed in 5 infants with hydrocephalus, and 1 adult patient with diffuse hypoxic ischemic brain injury. By facilitating timely detection of intracranial hypertension, this approach has potential to reduce risk of brain damage in hydrocephalus and other vulnerable patient populations.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740F (11 July 2019); doi: 10.1117/12.2527122
Show Author Affiliations
Wesley B. Baker, The Children's Hospital of Philadelphia (United States)
Tracy M. Flanders, The Children's Hospital of Philadelphia (United States)
Ramani Balu, Univ. of Pennsylvania (United States)
Lian He, Univ. of Pennsylvania (United States)
Kristina Heye, The Children's Hospital of Philadelphia (United States)
Elizabeth Mahanna Gabrielli, Univ. of Pennsylvania (United States)
John J. Flibotte, The Children's Hospital of Philadelphia (United States)
Daniel J. Licht, The Children's Hospital of Philadelphia (United States)
Gregory G. Heuer, The Children's Hospital of Philadelphia (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
W. Andrew Kofke, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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