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Proceedings Paper

Evaluation of arthritis with model rats using photoacoustic imaging system
Author(s): Kohei Ogawa; Takeshi Namita; Kengo Kondo; Makoto Yamakawa; Tsuyoshi Shiina
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Paper Abstract

Associated with local articular rigidity, swelling and pain as well as systemic development of fever and a sense of fatigue, arthritis is a disorder causing deterioration of patients’ quality of life. Approximately 300,000 patients report rheumatoid arthritis, one of the typical chronic joint inflammation, in Japan alone: 1% of the world’s population has the disorder worldwide. Although X-ray CT, MRI, and ultrasonic Doppler method are used for examination and diagnosis, various problems exist such as radiation exposure, administration of contrast agents and difficulty in earlier diagnosis and quantitative evaluation. To resolve these difficulties, we developed a handheld photoacoustic imaging system. In this study, the feasibility of evaluating the degree of inflammation using photoacoustic imaging with multiple wavelengths was investigated with in vivo measurements of model rats. The changes in signal intensity depending on the presence or absence of the disorder was examined. It was confirmed that the signal intensity can be intensified at diseased joints. Then, the changes with different time elapsed from drug administration was examined using rats. It was clarified that the degree of inflammation can be evaluated by shapes of photoacoustic spectra, which changed along with the progress of the inflammation. Through these analyses, we verified the usefulness of photoacoustic imaging for the diagnosis and evaluation of arthritis.

Paper Details

Date Published: 19 July 2019
PDF: 4 pages
Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 110771J (19 July 2019); doi: 10.1117/12.2527104
Show Author Affiliations
Kohei Ogawa, Graduate School of Medicine, Koyoto Univ. (Japan)
Takeshi Namita, Graduate School of Medicine, Koyoto Univ. (Japan)
Kengo Kondo, Graduate School of Medicine, Koyoto Univ. (Japan)
Makoto Yamakawa, Graduate School of Medicine, Koyoto Univ. (Japan)
Tsuyoshi Shiina, Graduate School of Medicine, Koyoto Univ. (Japan)

Published in SPIE Proceedings Vol. 11077:
Opto-Acoustic Methods and Applications in Biophotonics IV
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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