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Proceedings Paper

An endomicroscopic OCT for clinical trials in the field of ENT
Author(s): M. Ahrens; C. Idel; A. Chaker; B. Wollenberg; P. König; H. Schulz-Hildebrandt; G. Hüttmann
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Paper Abstract

Changes in the structure of the nasal mucosa can be a morphological biomarker and therefore helpful for diagnosis and follow-up of various pulmonary diseases such as asthma, cystic fibrosis and primary ciliary dyskinesia. In order to verify that microscopic optical coherence tomography (mOCT) is a valuable instrument for the investigation of those changes, an endoscopic OCT system with microscopic resolution (emOCT) was developed and built for clinical testing. The endoscope is based on a graded-index (GRIN) lens optic and provides a calculated lateral resolution of 0.7 μm and an axial resolution of 1.25 μm. The imaging depth was up to 500 μm in tissue; axially, a lateral range of approximate 250 μm could be covered. B-scans were acquired at 80 Hz with 512 pixels in lateral and 1024 pixels in depth-direction. The diameter of the endoscope decreases over a length of 8 cm from 8 mm at the beginning to 1.4 mm at the end and is small enough to observe the mucous membrane in the human nasal concha media and inferior down to the nasopharynx. The emOCT workstation was designed to meet German electrical, optical and biological safety standards. The applicability of the endoscope could be demonstrated in vivo. Mucus transport, glands, blood and lymphatic vessels could be visualized.

Paper Details

Date Published: 19 July 2019
PDF: 4 pages
Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110730U (19 July 2019); doi: 10.1117/12.2527099
Show Author Affiliations
M. Ahrens, Univ. zu Lübeck (Germany)
C. Idel, Univ. Schleswig-Holstein (Germany)
A. Chaker, Helmholtz Zentrum München GmbH (Germany)
B. Wollenberg, Univ. Schleswig-Holstein (Germany)
P. König, Univ. zu Lübeck (Germany)
H. Schulz-Hildebrandt, Univ. zu Lübeck (Germany)
G. Hüttmann, Univ. zu Lübeck (Germany)

Published in SPIE Proceedings Vol. 11073:
Clinical and Preclinical Optical Diagnostics II
J. Quincy Brown; Ton G. van Leeuwen, Editor(s)

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