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Hybrid technique for characterization of human skin using a combined machine learning and inverse Monte Carlo approach
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Paper Abstract

We have recently introduced a novel methodology for noninvasive assessment of structure and composition of human skin in vivo. The approach combines pulsed photothermal radiometry (PPTR), involving time-resolved measurements of midinfrared emission after irradiation with a millisecond light pulse, and diffuse reflectance spectroscopy (DRS) in visible part of the spectrum (400–600 nm). The experimental data are fitted simultaneously with respective predictions from a four-layer Monte Carlo (MC) model of light transport in human skin. The described approach allows assessment of the contents of specific chromophores (melanin, oxy-, and deoxyhemoglobin), as well as scattering properties and thicknesses of the epidermis and dermis. However, the involved multidimensional optimization with a numerical forward model (i.e., inverse MC, IMC) is computationally very expensive. In addition, each optimization task is repeated several times to control the inevitable numerical noise and facilitate escape from local minima. Thus, assessment of 14 free parameters from each radiometric transient and DRS spectrum takes several hours despite massive parallelization using CUDA technology and a high-performance graphics card. To alleviate this limitation, we have developed a computationally very efficient predictive model (PM) based on machine learning technology. The PM is an ensemble of decision trees (random forest), trained using ~10,000 "pairs" of various skin parameter combinations and the corresponding PPTR signals and DRS spectra, computed using our forward MC model. While the parameter values predicted by the PM are very similar to the IMC results there are some concerns regarding their accuracy. Therefore, we present here a hybrid model, which combines the described PM and IMC approaches.

Paper Details

Date Published: 22 July 2019
PDF: 8 pages
Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751K (22 July 2019); doi: 10.1117/12.2526997
Show Author Affiliations
N. Verdel, Jožef Stefan Institute (Slovenia)
J. Tanevski, Jožef Stefan Institute (Slovenia)
S. Džeroski, Jožef Stefan Institute (Slovenia)
B. Majaron, Jožef Stefan Institute (Slovenia)
Univ. of Ljubljana (Slovenia)


Published in SPIE Proceedings Vol. 11075:
Novel Biophotonics Techniques and Applications V
Arjen Amelink; Seemantini K. Nadkarni, Editor(s)

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