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Effect of hepatic vein on gold nanoparticle-mediated-hyperthermia in liver cancer
Author(s): Mandana Jalali; Paul Mertin; Andreas Rennings; Daniel Erni
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Paper Abstract

Gold nanoparticle-mediated hyperthermia is a non-invasive, target-based cancer treatment with significantly reduced side effects compared to conventional treatments. In this work a simulation model for gold nanoparticlemediated hyperthermia is set up and used to investigate the case of a liver tumor located in the vicinity of a hepatic vein. Gold nanorods with optimized size and aspect ratio are embedded within the liver, and the temperature raise under CW laser illumination is calculated, while taking into account the convective heat transfer through blood perfusion. For this purpose, an analytical model based on the Navier-Stokes equation is used. Results show that due to the heat drain in the blood stream, an effective temperature raise is not achievable when the tumor is located in the vicinity of the hepatic vein. Additionally it is shown that even in the case of a 90% occluded vein, the temperature raise with such nanoparticle arrangement is still not enough for tumor ablation.

Paper Details

Date Published: 3 October 2019
PDF: 6 pages
Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112070M (3 October 2019); doi: 10.1117/12.2526978
Show Author Affiliations
Mandana Jalali, Univ. Duisburg-Essen (Germany)
Ctr. for Nanointegration Duisberg-Essen (Germany)
Paul Mertin, Ruhr-Univ. Bochum (Germany)
Andreas Rennings, Univ. Duisburg-Essen (Germany)
Ctr. for Nanointegration Duisberg-Essen (Germany)
Daniel Erni, Univ. Duisburg-Essen (Germany)
Ctr. for Nanointegration Duisberg-Essen (Germany)


Published in SPIE Proceedings Vol. 11207:
Fourth International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. M. Martins Costa, Editor(s)

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