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Proceedings Paper

Ex vivo and in vivo imaging of human brain tissue with different OCT systems
Author(s): P. Strenge; B. Lange; C. Grill; W. Draxinger; V. Danicke; D. Theisen-Kunde; M. Bonsanto; R. Huber; R. Brinkmann
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Paper Abstract

Optical coherence tomography (OCT) is a non-invasive imaging technique which is currently investigated for intraoperative detection of residual tumor during resection of human gliomas. Three different OCT systems were used for imaging of human glioblastoma in vivo (830nm spectral domain (SD) OCT integrated into a surgical microscope) and ex vivo (940nm SD-OCT and 1310nm swept-source MHz-OCT using a Fourier domain mode locked (FDML) laser). Before clinical data acquisition, the systems were characterized using a three-dimensional point-spread function phantom. To distinguish tumor from healthy brain tissue later on, attenuation coefficients of each pixel in OCT depth profiles are calculated. First examples from a clinical study show that the pixel-resolved calculation of the attenuation coefficient provides a good image contrast and confirm that white matter shows a higher signal and more homogeneous signal structure than tumorous tissue.

Paper Details

Date Published: 19 July 2019
PDF: 7 pages
Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781C (19 July 2019); doi: 10.1117/12.2526932
Show Author Affiliations
P. Strenge, Medical Laser Ctr. Lübeck (Germany)
B. Lange, Medical Laser Ctr. Lübeck (Germany)
C. Grill, Univ. zu Lübeck (Germany)
W. Draxinger, Univ. zu Lübeck (Germany)
V. Danicke, Univ. zu Lübeck (Germany)
D. Theisen-Kunde, Medical Laser Ctr. Lübeck (Germany)
M. Bonsanto, Univ. Medical Ctr. Schleswig-Holstein (Germany)
R. Huber, Univ. zu Lübeck (Germany)
R. Brinkmann, Medical Laser Ctr. Lübeck (Germany)
Univ. zu Lübeck (Germany)

Published in SPIE Proceedings Vol. 11078:
Optical Coherence Imaging Techniques and Imaging in Scattering Media III
Maciej Wojtkowski; Stephen A. Boppart; Wang-Yuhl Oh, Editor(s)

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