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Proceedings Paper

Functionalized upconversion luminescent nanoparticles for theranostics
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Paper Abstract

The luminescence spectra of upconversion nanoparticles (UCNPs) and functionalized UCNPs (UCNPs+folic acid) delivered via subcutaneous and intratumor injection into rats were measured. The particles in normal skin do not diffuse and dissolve, but remain at the introduction site. Inflammatory reaction is developing in the skin when UCNPs were injected. The dense connective tissue capsule is formed around the particles in 3 days after administration. UCNPs were located in the tumor diffusely after 4 daysof injection. Up to 80-90% of the tumor was necrotized after laser irradiation on the fourth day after UCNP administration.

Paper Details

Date Published: 11 July 2019
PDF: 8 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107419 (11 July 2019); doi: 10.1117/12.2526930
Show Author Affiliations
Irina Yu Yanina, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Nikita A. Navolokin, Saratov State Medical Univ. (Russian Federation)
Irina V. Vidyasheva, Saratov National Research State Univ. (Russian Federation)
Irina Yu. Goryacheva, Saratov National Research State Univ. (Russian Federation)
Vyacheslav I. Kochubey, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Valery V. Tuchin, Saratov National Research State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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