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Proceedings Paper

Effects of ultrasound impedance matching fluids on diffuse optical measurements
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Paper Abstract

Diffuse optical imaging can be used to probe highly scattering media like biological tissue down to a depth of few centimeters, with spatial resolution limited by light scattering. Its combination with ultrasound imaging can potentially lead to medical imaging systems with, for instance, high specificity in the examination of tumors. However, the presence of the ultrasound coupling gel between probe and tissue can have detrimental effects on the accuracy of optical imaging techniques. Here we present an experimental study on the effect of ultrasound coupling fluids on diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS). We demonstrate on tissue-mimicking phantoms that the use of standard water-clear gels, providing a direct path for the light from the source to the detection point, can distort optical measurements generating strong underestimation of both the absorption and the reduced scattering coefficients in DOS measurements, as well as underestimation of the Brownian diffusion coefficient in DCS measurements. On the contrary, various turbid fluids demonstrate excellent performance in preventing this issue.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742T (11 July 2019);
Show Author Affiliations
Laura Di Sieno, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Giuseppe Lo Presti, ICFO - Institut de Ciències Fotòniques (Spain)
Lorenzo Cortese, ICFO - Institut de Ciències Fotòniques (Spain)
Tony Mateo, Vermon S.A. (France)
Bogdan Rosinski, Vermon S.A. (France)
Elena Venturini, Scientific Institute Ospedale San Raffaele (Italy)
Pietro Panizza, Scientific Institute Ospedale San Raffaele (Italy)
Mireia Mora, Institut d'Investigacions Biomèdiques Agustí Pi Sunyer (Spain)
Gloria Aranda, Institut d'Investigacions Biomèdiques Agustí Pi Sunyer (Spain)
Mattia Squarcia, Institut d'Investigacions Biomèdiques Agustí Pi Sunyer (Spain)
Andrea Farina, CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Paola Taroni, Politecnico di Milano (Italy)
CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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