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Proceedings Paper

Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury
Author(s): Gemma Bale; Ajay Rajaram; Matthew Kewin; Laura Morrison; Alan Bainbridge; Linshan Liu; Udunna Anazodo; Mamadou Diop; Keith St. Lawrence; Ilias Tachtsidis
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Paper Abstract

This is the first multimodal study of cerebral tissue metabolism and perfusion post-hypoxic-ischaemic (HI) brain injury with broadband near-infrared spectroscopy (bNIRS), diffuse correlation spectroscopy (DCS), positron emission tomography (PET) and magnetic resonance spectroscopy (MRS). In 5 piglet models of HI, we measured cerebral tissue saturation (StO2), cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO2), changes in the mitochondrial oxidation state of cytochrome-c-oxidase (oxCCO), cerebral glucose metabolism (CMRglc), and tissue biochemistry (Lac+Thr/tNAA). At baseline, the parameters measured were: 64±6 % StO2, 35±11 ml/100g/min CBF, and 2.0±0.4 μmol/100g/min CMRO2. After HI the parameters measured were: 68±6% StO2, 35±6 ml/100g/min CBF, 1.3±0.1 μmol/100g/min CMRO2, 0.4±0.2 Lac+Thr/tNAA, and 9.5±2.0 CMRglc. This study demonstrates the capacity of a multimodal set up to interrogate the pathophysiology of HIE using a combination of optical methods, MRS, and PET.

Paper Details

Date Published: 11 July 2019
PDF: 3 pages
Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107414 (11 July 2019); doi: 10.1117/12.2526729
Show Author Affiliations
Gemma Bale, Univ. College London (United Kingdom)
Ajay Rajaram, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Matthew Kewin, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Laura Morrison, Lawson Health Research Institute (Canada)
Alan Bainbridge, Univ. College Hospital (United Kingdom)
Linshan Liu, Lawson Health Research Institute (Canada)
Udunna Anazodo, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Mamadou Diop, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Keith St. Lawrence, Lawson Health Research Institute (Canada)
Western Univ. (Canada)
Ilias Tachtsidis, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 11074:
Diffuse Optical Spectroscopy and Imaging VII
Hamid Dehghani; Heidrun Wabnitz, Editor(s)

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