Share Email Print

Proceedings Paper

Treatment of peritoneal carcinomatosis of various origins by photodynamic therapy: state of the art (Conference Presentation)

Paper Abstract

The surgical management of peritoneal metastases, whatever their origin, raises the problem of the potential involvement of the entire peritoneal serosa. Peritoneal metastases are surface lesions, sometimes numerous, extensive, and they may be theoretically accessible to photodynamic therapy (PDT). Intraperitoneal applications of PDT are limited by the photosensitizers lack of specificity, that should explain side effects and complications observed in the past, and by the difficulties to bring light into the cavity. Past clinical evaluations had demonstrated the risks associated with this technique (capillary leak syndrome, anastomotic leakages), and no trial evaluating PDT for peritoneal metastases treatment was published since 2006. Recent data may contribute to give a new breath for this technique. Indeed, new targeted molecules are being developed, and the optimization of illumination systems makes possible the implementation of PDT by minimally invasive approaches (laparoscopy). Immunotherapy also brings new arguments to promote PDT in this indication. Indeed, it is unrealistic to think that surgery alone can ensure satisfactory microscopic cytoreduction quality and the application of light uniformly over the whole peritoneal surface cannot be reasonably considered. Thus, the expected abscopal effect of PDT could enhance a systemic immune response leading to better control of residual lesions on the one hand, and also peritoneal and tissue recurrences at a distance. The objective of this review is to present the most recent data and possible approaches for the treatment of peritoneal carcinomatosis by PDT.

Paper Details

Date Published: 14 August 2019
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107026 (14 August 2019); doi: 10.1117/12.2526638
Show Author Affiliations
Henri Azaïs, Pitié-Salpêtrière Hospital (France)
OncoThAI INSERM (France)
Martha Baydoun, Institut de Biologie de Lille (France)
Christie Rebahi, Institut de Biologie de Lille (France)
Olivier Moralès, Institut de Biologie de Lille (France)
Céline Frochot, Lab. Réactions et Génie des Procédés (France)
Ludovic Colombeau, Lab. Réactions et Génie des Procédés (France)
Bertrand Leroux, OncoThAI INSERM (France)
Elise Thécua, OncoThAI INSERM (France)
Nadira Delhem, CNRS (France)
Pierre Collinet, Hôpital Jeanne de Flandre (France)
OncoThAI INSERM (France)
Serge Mordon, OncoThAI INSERM (France)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?