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Proceedings Paper

Nonlinear imaging of female breast tissue biopsies
Author(s): Evangelia Gavgiotaki; Vassilis Tsafas; Savvas Bovasianos; Sofia Agelaki; Vassilis Georgoulias; Maria Tzardi; Irene Athanassakis; George Filippidis
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Paper Abstract

In this study nonlinear microscopy techniques utilized to shed new light in breast cancer diagnosis. In particular, the nonlinear imaging modalities of multi-photon excitation fluorescence (MPEF) second and third harmonic generation (SHG, THG) used as non-destructive, label free diagnostic tools for the qualitative discrimination of breast cancer tissues. Nonlinear signals were collected from unstained thin histological sections of breast biopsies samples. In an attempt to discriminate the different types of tissues, quantitative analysis of the recorded THG signals on specific cells in tissue was also performed.

Paper Details

Date Published: 22 July 2019
PDF: 6 pages
Proc. SPIE 11076, Advances in Microscopic Imaging II, 110760I (22 July 2019);
Show Author Affiliations
Evangelia Gavgiotaki, Foundation for Research and Technology (Greece)
Univ. of Crete (Greece)
Vassilis Tsafas, Foundation for Research and Technology (Greece)
Univ. of Crete (Greece)
Savvas Bovasianos, Foundation for Research and Technology (Greece)
Univ. of Crete (Greece)
Sofia Agelaki, Univ. of Crete (Greece)
Vassilis Georgoulias, Univ. of Crete (Greece)
Maria Tzardi, Univ. of Crete (Greece)
Irene Athanassakis, Univ. of Crete (Greece)
George Filippidis, Foundation for Research and Technology (Greece)


Published in SPIE Proceedings Vol. 11076:
Advances in Microscopic Imaging II
Emmanuel Beaurepaire; Francesco Saverio Pavone; Peter T. C. So, Editor(s)

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