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Proceedings Paper

Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics
Author(s): Alexey Lihachev; Emilija Vija Plorina; Marta Lange; Ilze Lihacova; Alexander Derjabo; Dmitrijs Bliznuks
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Paper Abstract

The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

Paper Details

Date Published: 19 July 2019
PDF: 3 pages
Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 110731S (19 July 2019); doi: 10.1117/12.2526260
Show Author Affiliations
Alexey Lihachev, Univ. of Latvia (Latvia)
Emilija Vija Plorina, Univ. of Latvia (Latvia)
Marta Lange, Univ. of Latvia (Latvia)
Ilze Lihacova, Univ. of Latvia (Latvia)
Alexander Derjabo, SIA Riga Eastern Clinical Univ. Hospital (Latvia)
Dmitrijs Bliznuks, Riga Technical Univ. (Latvia)

Published in SPIE Proceedings Vol. 11073:
Clinical and Preclinical Optical Diagnostics II
J. Quincy Brown; Ton G. van Leeuwen, Editor(s)

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