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Proceedings Paper

Quantum dot light emitting diodes (QLEDs) as low-cost PDT light sources (Conference Presentation)
Author(s): Hao Chen; Peter Palomaki; Juan He; Raymond Lanzafame; Istvan Stadler; Hamid El-Hamidi; Hui Liu; Jonathan Celli; Michael Hamblin; Yingying Huang; Gal Shafirstein; Ho-Kyoon Chung; Shin-Tson Wu; Yajie Dong

Paper Abstract

Homogeneous, flexible light sources with pure, deep red color and sufficiently high power densities are necessary for more effective and widely used photodynamic therapy (PDT), but have been difficult to achieve with lasers or LED arrays at reasonably low cost. Quantum dot light emitting diodes (QLEDs) have outstanding wavelength tunability, ideal color purity, sufficient power density and unique form factors as thin, flexible, light weight and uniformly large area light sources, which will meet the pressing needs for PDT. Here we report QLEDs fabricated with emission wavelengths precisely tuned to match the absorption peaks of several FDA approved photosensitizers. Preliminary in-vitro studies with rigid on-glass QLEDs as photosensitizer activators demonstrate they can kill cancerous A431 cells or Methicillin-resistant Staphylococcus aureus (MRSA) with efficiency comparable or better than control LED sources, indicating their potential for PDT treatments of cancers or infections. Computer simulation of light propagation in a tissue mimicking phantom suggests that about 50% of the QLED power can be delivered to a depth of about 4 mm from the treated surface. Recent progress on the fabrication of low-cost flexible QLEDs will be presented. Finally, the perspectives of using these devices for PDT to address medical conditions such as cancer treatment, wound repair or cosmetic dermatology will be discussed.

Paper Details

Date Published: 14 August 2019
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Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107056 (14 August 2019); doi: 10.1117/12.2525829
Show Author Affiliations
Hao Chen, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Peter Palomaki, QLEDCures, LLC (United States)
Juan He, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Raymond Lanzafame, QLEDCures, LLC (United States)
Raymond J. Lanzafame MD PLLC (United States)
Istvan Stadler, Rochester General Hospital (United States)
Hamid El-Hamidi, Univ. of Massachusetts Boston (United States)
Hui Liu, Univ. of Massachusetts Boston (United States)
Jonathan Celli, Univ. of Massachusetts Boston (United States)
Michael Hamblin, Wellman Ctr. for Photomedicine (United States)
Harvard Medical School (United States)
Yingying Huang, Harvard Medical School (United States)
Wellman Ctr. for Photomedicine (United States)
Gal Shafirstein, Roswell Park Comprehensive Cancer Ctr. (United States)
Ho-Kyoon Chung, Sungkyunkwan Univ. (Korea, Republic of)
Shin-Tson Wu, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Yajie Dong, Univ. of Central Florida (United States)
QLEDCures, LLC (United States)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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