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Proceedings Paper

Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines
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Paper Abstract

Solubility of (aza)phthalocyanines ((Aza)Pc) in water is very limited due to their flat aromatic core that makes them prone to aggregation. Stacking of (Aza)Pc cores (forming dimers or higher-order aggregates) leads to quenching of their excited states – fluorescence and 1O2 production [1]. Several approaches to improve the solubility have been described, but truly non aggregating water-soluble (Aza)Pcs are still scarce [2-7]. Here we present a series of novel water-soluble hydrophilic and amphiphilic zinc (Aza)Pcs with differently charged (cationic and anionic) as well as non-charged peripheral substituents. These compounds were directly compared to several clinically approved photosensitizers (PSs; verteporfin, temoporfin, Photosens, methylene blue and protoporphyrin IX – a photodynamically active product of a prodrug 5-aminolevulinic acid).

Paper Details

Date Published: 7 August 2019
PDF: 4 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110709M (7 August 2019); doi: 10.1117/12.2525591
Show Author Affiliations
Miloslav Macháček, Charles Univ. (Czech Republic)
Jan Kollár, Charles Univ. (Czech Republic)
Marie Halašková, Charles Univ. (Czech Republic)
Monika Steklá, Charles Univ. (Czech Republic)
Saad Makhseed, Kuwait Univ. (Kuwait)
Tomáš Šimůnek, Charles Univ. (Czech Republic)
Petr Zimčík, Charles Univ. (Czech Republic)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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