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The effect of heme biosynthesis on the mitochondrial functions in C2C12 cels
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Paper Abstract

Mitochondria play a fundamental role in generating of energy in cells. Electron transfer in electron transport chain (ETC) involved in mitochondria was one of the biological functions of heme. Heme biosynthesizes increased upon the addition of 5-aminolevulinic acid (ALA). Complex I and II protein expression were downregulated, while complex IV and cytochrome c expression were upregulated by the addition of ALA. Administration of ALA significantly increased Complex IV (COX) activity and cellular ATP level. Surprisingly, the mitochondrial content and mitochondrial membrane potential were unchanged. Consistently, the relative mRNA-expression of transcription factors affecting mitochondrial biogenesis was unchanged after the addition of ALA.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070A4 (7 August 2019); doi: 10.1117/12.2525559
Show Author Affiliations
Arif Suprihadi, Tokyo Institute of Technology (Japan)
Hung Wei Lai, Tokyo Institute of Technology (Malaysia)
Hui Sun Tan, Tokyo Institute of Technology (Japan)
Kiwamu Takahashi, SBI Pharmaceuticals Co., Ltd. (Japan)
Motowo Nakajima, SBI Pharmaceuticals Co., Ltd. (Japan)
Tohru Tanaka, SBI Pharmaceuticals Co., Ltd. (Japan)
Shun-ichiro Ogura, Tokyo Institute of Technology (Japan)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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