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Proceedings Paper

The influence of hypericin-mediated photodynamic therapy on secretion of selected interleukins by colon cancer cells in vitro
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Paper Abstract

Aim of the study was to determine the immune effect of PDT with hypericin (HY-PDT) used in sublethal doses on the secretion of Interleukin 8 and 10 by experimental models of residual colon cancer cells in vitro. Results HY-PDT amplified the secretion of IL-8 by SW620 cell line, but the decrease of IL-8 secreted by the SW480 cell line. The increase in secretion of IL-10 was noticed in the SW480 cell line, but the changes of secretion IL-10 by SW 620 was not noted. SW480 cell line without PDT secreted higher levels of IL-8 and IL-10 than SW620 cells. Based on these research findings it could be told, that PDT both eliminates and control primary tumors using cytotoxic effect while HY-PDT at lower doses can modulate function of tumor microenvironment by releasing interleukins depended on metastatic activity of tumor cells.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070A2 (7 August 2019); doi: 10.1117/12.2525516
Show Author Affiliations
Aleksandra Kawczyk-Krupka, Medical Univ. of Silesia (Poland)
Marta Kaleta-Richter, Medical Univ. of Silesia (Poland)
Anna Miedzybrodzka, Medical Univ. of Silesia (Poland)
Wojciech Latos, Medical Univ. of Silesia (Poland)
Aleksander Sieron, Jan Dlugosz Univ. de Czestochowa (Poland)
Grzegorz Cieslar, Medical Univ. of Silesia (Poland)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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