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Proceedings Paper

Design of an optofluidic device for the measurement of the elastic modulus of deformable particles
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Paper Abstract

Suspensions carrying deformable inclusions are ubiquitous in nature and applications. Hence, high-throughput characterization of the mechanical properties of soft particles is of great interest. Recently, a non-invasive optofluidic technique has been developed for the measurement of the interfacial tension between two immiscible liquids.1, 2 We adapt such technique to the case of soft solid beads, thus designing a non-invasive optofluidic device for the measurement of the mechanical properties of deformable particles from real-time optical imaging of their deformation. The device consists of a cylindrical microfluidic channel with a cross-section reduction in which we make initially spherical soft beads flow suspended in a Newtonian carrier. By imaging the deformation of a particle in real time while it goes through the constriction, it is possible to get a measure of its elastic modulus through a theoretically derived-correlation. We provide both experimental and numerical validation of our device.

Paper Details

Date Published: 21 June 2019
PDF: 12 pages
Proc. SPIE 11060, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV, 110600L (21 June 2019); doi: 10.1117/12.2524901
Show Author Affiliations
Massimiliano M. Villone, Univ. degli Studi di Napoli Federico II (Italy)
Janine K. Nunes, Princeton Univ. (United States)
Yankai Li, Princeton Univ. (United States)
Howard A. Stone, Princeton Univ. (United States)
Pier Luca Maffettone, Univ. degli Studi di Napoli Federico II (Italy)


Published in SPIE Proceedings Vol. 11060:
Optical Methods for Inspection, Characterization, and Imaging of Biomaterials IV
Pietro Ferraro; Simonetta Grilli; Monika Ritsch-Marte; Christoph K. Hitzenberger, Editor(s)

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