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Proceedings Paper

Use of dynamic light scattering for assessing acute pain
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Paper Abstract

Currently there is no accurate objective measure for monitoring pain during the state of drug-induced unconsciousness (such as during surgical anesthesia). Moreover, the absence of an objective measure for detecting pain hampers the physician's ability to provide an optimal dose of analgesics. We have developed a novel method for detecting pain by quantifying skin blood flow dynamics using a miniaturized dynamic light scattering (mDLS) sensor placed on the skin. Healthy awake volunteers were studied with mDLS sensors placed on both index fingers while being subjected to a series of cutaneous painful stimuli (electric shock and heat), randomly applied in a range between the subjects’ pain threshold and tolerance. Power spectrum analysis of the recorded signal was performed with a focus on two frequency bands, representing relative blood flow of non-pulsatile vessels and larger pulsatile arterioles. Relative blood flow of pulsatile vessels decreased while flow of non-pulsatile vessels increased in response to painful stimulation, with a high correlation between the responses obtained on the right and left index fingers. The changes in hemodynamics that occur during painful stimulation suggest a redistribution of blood flow between pulsatile and non-pulsatile vessels, probably related to central activation of the sympathetic system combined with local dynamic autoregulatory responses. Thus, optical parameters of skin blood flow can detect nociceptive stimuli and consequently can serve as objective biomarkers of pain.

Paper Details

Date Published: 22 July 2019
PDF: 10 pages
Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750N (22 July 2019); doi: 10.1117/12.2524523
Show Author Affiliations
Suzanne Broens, Leiden Univ. Medical Ctr. (Netherlands)
Adi Schejter Bar-Noam, Elfi-Tech Ltd. (Israel)
Ilya Fine, Elfi-Tech Ltd. (Israel)
Louis Shenkman, Tel Aviv Univ. (Israel)
Monique van Velzen, Leiden Univ. Medical Ctr. (Netherlands)
Marieke Niesters, Leiden Univ. Medical Ctr. (Netherlands)
Albert Dahan, Leiden Univ. Medical Ctr. (Netherlands)

Published in SPIE Proceedings Vol. 11075:
Novel Biophotonics Techniques and Applications V
Arjen Amelink; Seemantini K. Nadkarni, Editor(s)

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