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Proceedings Paper

Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake
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Paper Abstract

Aminolevulinic acid–based photodynamic therapy (ALA-PDT) has emerged as a new alternative for chemotherapy in cancer treatment due to its high specificity and low side effects. We added siRNAs and inhibitors of transporters to study the roles of transporters in ALA uptake in sets of normal and cancer cell lines. PEPT1 and PAT1 were expressed only in normal lung and prostate cells, respectively, but not in their cancerous counterparts. Inhibition of these transporters showed a significant decrease in PpIX production only in normal cells. PEPT1 and PAT1 transporter inhibitors could be possible new drugs to increase the specificity of ALA-PDT.

Paper Details

Date Published: 7 August 2019
PDF: 1 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110706I (7 August 2019); doi: 10.1117/12.2524522
Show Author Affiliations
Hung Wei Lai, Tokyo Institute of Technology (Japan)
Ryuta Sasaki, Tokyo Institute of Technology (Japan)
Shiro Usuki, Tokyo Institute of Technology (Japan)
Motowo Nakajima, SBI Pharmaceuticals Co., Ltd. (Japan)
Tohru Tanaka, SBI Pharmaceuticals Co., Ltd. (Japan)
Shun-Ichiro Ogura, Tokyo Institute of Technology (Japan)


Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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