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Proceedings Paper

Effect of ethanol on the transport of methylene blue through the rat skin ex vivo
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Paper Abstract

The main goal of the study is to investigate the effect of ethanol aqueous solutions with volume concentrations 30, 40, and 50% on the transport of Methylene Blue (MB) in rat skin ex vivo. The concentration dependences of MB absorbance in optical phantoms mimicking skin optical properties were measured. It has been obtained, for skin-like optical phantoms with low MB concentration (less than 0.025 mg/mL) the concentration dependence of MB absorption coefficient can be taken as linear in a first approximation. The study has shown that the diffusion rate grows with the increase of ethanol concentration in the solutions. The rate is 1.6 folds higher for 50%-ethanol solution of MB than when aqueous solution of MB is used. Effective diffusion coefficients of MB in skin samples have been evaluated as (3.34±0.07)×10-6 cm2/sec, (3.04±0.07)×10-6 cm2/sec, (2.59±0.07)×10-6 cm2 /sec, and (1.85±0.06)×10-7 cm2/sec for 50%, 40%, 30% ethanol solutions and aqueous solution, respectively. The characteristic time has the following values: 24.6±4.4 min, 40.1±3.2 min, 46.8±2.7 min, and 79.4±11.9 min for 50%, 40%, 30% aqueous ethanol solutions and aqueous solution, respectively.

Paper Details

Date Published: 3 June 2019
PDF: 8 pages
Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106509 (3 June 2019); doi: 10.1117/12.2524460
Show Author Affiliations
Elizaveta A. Basko, Saratov State Univ. (Russian Federation)
Maria V. Klementeva, Saratov State Univ. (Russian Federation)
Alexey N. Bashkatov, Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)
Elina A. Genina, Saratov State Univ. (Russian Federation)
National Research Tomsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11065:
Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine
Elina A. Genina; Valery V. Tuchin, Editor(s)

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